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About Delgra

Delgra is composed of Sildenafil Citrate which is the most potent treatment for Erectile Dysfunction.Delgra contains citrate of Sildenafil a selective inhibitor of cyclic guanosine monophosphate (cGMP) specific phosphodiesterase type 5 (PDE5).

Delgra is designated chemically as 1-[[3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3d]pyrimidin-5-yl)-4 ethoxyphenyl]sulfonyl]-4-methylpiperazine citrate.

Delgra is a white to off-white crystalline powder with a solubility of 3.5 mg/mL in water and a molecular weight of 666.7.

In the corpus cavernosum Delgra protects cyclic guanosine monophosphate (cGMP) from degradation by cGMP-specific phosphodiesterase type 5 (PDE5).In the penis nitric oxide (NO) binds to guanylate cyclase receptors of the corpus cavernosum. This results in increases of the levels of cyclic guanosine monophosphate leading to smooth muscle relaxation. This smooth muscle relaxation leads to vasodilation which increases the inflow of blood into the penis resulting in firm erection.

Delgra is a potent and selective inhibitor of cGMP-specific phosphodiesterase type 5 (PDE5). cGMP-specific phosphodiesterase type 5 (PDE5) is responsible for lowering the levels of cGMP in the corpus cavernosum. The molecular structure of Delgra is similar to that of cGMP and acts as a competitive binding agent of PDE5 in the corpus cavernosum.This results in the increase of levels cGMP and better erections.Other drugs that operate by the same mechanism include Tadadel,Lovevitra and Sai Avana.

Delgra is broken down in the liver by hepatic metabolism.This process is accomplished using cytochrome p450 enzymes and CYP2C9 hepatic isoenzymes. The major product of metabolisation by these enzymes is N-desmethylated sildenafil, which is further metabolized. This metabolite also has an affinity for the PDE receptors about 40% of that of Delgra. Thus the metabolite is responsible for about 20% of Delgra’s action.About 80% of administered oral dose of Delgra is excreted as metabolites mostly in the feces .About 13% of administered oral dose of Delgra is excreted in the urine. The absorption is reduced if Delgra is take with a high fat meal. The time taken to reach the maximum plasma levels goes up by around one hour and the maximum concentration itself is decreased by nearly one-third.